解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Fibroblast growth factors FGF-1 and FGF-2 are often upregulated in tumors, but tightly bound to heparan sulphate proteoglycans of the extracellular matrix (ECM). One mechanism of their bioactivation relies on the FGF-binding protein (FGF-BP) which, upon reversible binding to FGF-1 or -2, leads to their relea...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-144
更新日期:2011-11-23 00:00:00
abstract:BACKGROUND:SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression. In our previous work we detected SOX2 in glioma cells and glioblastoma...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-137
更新日期:2011-11-09 00:00:00
abstract:BACKGROUND:In previously published studies, oncolytic adenovirus-mediated gene therapy has produced good results in targeting cancer cells. However, safety and efficacy, the two most important aspects in cancer therapy, remain serious challenges. The specific expression or deletion of replication related genes in an ad...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-133
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through which Aurora-A activity ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-131
更新日期:2011-10-19 00:00:00
abstract:BACKGROUND:Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify different...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-124
更新日期:2011-09-30 00:00:00
abstract:BACKGROUND:In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinic...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-113
更新日期:2011-09-14 00:00:00
abstract:BACKGROUND:Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is still unclear. CD133 is a marker for adult stem cells in various tissues a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-94
更新日期:2011-07-29 00:00:00
abstract:BACKGROUND:Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cisplatin treatment, a bala...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-74
更新日期:2011-06-16 00:00:00
abstract:BACKGROUND:The pre-leukemia transcription factor 3 (PBX) is part of the PBX family of transcription factors, which is known to regulate genes involved in differentiation of urogenital organs and steroidogenesis. This is of interest with regard to prostate cancer progression as regulation of steroidogenesis is one of th...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-50
更新日期:2011-05-06 00:00:00
abstract:BACKGROUND:Tumor recurrence and metastasis develop as a result of tumors' acquisition of anti-apoptotic mechanisms and therefore, it is necessary to develop novel effective therapeutics against metastatic cancers. In this study, we showed the differential TRAIL responsiveness of human prostate adenocarcinoma PC3 and hu...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-46
更新日期:2011-04-25 00:00:00
abstract:BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-44
更新日期:2011-04-20 00:00:00
abstract:BACKGROUND:Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin. RESULTS:The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-c...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-32
更新日期:2011-03-29 00:00:00
abstract:BACKGROUND:Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We no...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-27
更新日期:2011-03-14 00:00:00
abstract:BACKGROUND:SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN pro...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-2
更新日期:2011-01-06 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-10-1
更新日期:2011-01-04 00:00:00
abstract:BACKGROUND:Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing the mechanisms by which perifosine enhances TRAIL-ind...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-315
更新日期:2010-12-20 00:00:00
abstract::The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostat...
journal_title:Molecular cancer
pub_type: 评论,杂志文章
doi:10.1186/1476-4598-9-308
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-298
更新日期:2010-11-22 00:00:00
abstract::Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-299
更新日期:2010-11-22 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern the chara...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-283
更新日期:2010-10-27 00:00:00
abstract:BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-281
更新日期:2010-10-26 00:00:00
abstract:BACKGROUND:TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition of cell proliferation and a strong activation of focal adhesion kinase (FAK). As dasatinib inhibi...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-278
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:Osteopontin (OPN) has been shown to play many roles in the progression of cancer. We have recently demonstrated the activation of Akt by OPN. Integrin-linked kinase and PI3-kinase are integral proteins in OPN/AKT pathway in PC3 cells. To investigate the role of the extracellular receptors in OPN signaling, w...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-260
更新日期:2010-09-26 00:00:00
abstract::Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories. Via interaction with its high affinity receptor Plexin-B1, Sema4...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/1476-4598-9-251
更新日期:2010-09-21 00:00:00
abstract::Monoclonal antibodies represent some of the most promising molecular targeted immunotherapies. However, understanding mechanisms by which tumors evade elimination by the immune system of the host presents a significant challenge for developing effective cancer immunotherapies. The interaction of cancer cells with the ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/1476-4598-9-242
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:Lung cancer is the most lethal cancer and almost 90% of lung cancer is due to cigarette smoking. Even though nicotine, one of the major ingredients of cigarette smoke and the causative agent for addiction, is not a carcinogen by itself, several investigators have shown that nicotine can induce cell prolifera...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-220
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:New blood vessel formation, or angiogenic switch, is an essential event in the development of solid tumors and their metastatic growth. Tumor blood vessel formation and remodeling is a complex and multi-step processes. The differentiation and recruitment of mural cells including vascular smooth muscle cells ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-209
更新日期:2010-08-05 00:00:00
abstract:BACKGROUND:The transcription factor Runx2 has an established role in cancers that metastasize to bone. In metastatic breast cancer cells Runx2 is overexpressed and contributes to the invasive capacity of the cells by regulating the expression of several invasion genes. CBFbeta is a transcriptional co-activator that is ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-171
更新日期:2010-06-30 00:00:00
abstract:BACKGROUND:CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer cells and a decreased ability of this receptor to induce cell death. ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-161
更新日期:2010-06-23 00:00:00
abstract::The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-150
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-137
更新日期:2010-06-03 00:00:00
abstract:BACKGROUND:Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS:To further elucidate th...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-133
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independen...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-131
更新日期:2010-05-30 00:00:00
abstract:BACKGROUND:Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a distinct hypersensitivity towards DNA interstrand-crosslinking (ICL)-agents, FA defects represent r...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-127
更新日期:2010-05-28 00:00:00
abstract:BACKGROUND:Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is strongly related to tumor cell adhesion to the extracellular matrix and alterations in the quantity a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-130
更新日期:2010-05-28 00:00:00
abstract:BACKGROUND:Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-122
更新日期:2010-05-26 00:00:00
abstract:BACKGROUND:MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-118
更新日期:2010-05-24 00:00:00
abstract:BACKGROUND:To test if the expression of Smad1-8 mRNAs were predictive of survival in patients with oral squamous cell carcinoma (SCC). PATIENTS AND METHODS:We analyzed, prospectively, the expression of Smad1-8, by means of Ribonuclease Protection Assay in 48 primary, operable, oral SCC. In addition, 21 larynx, 10 orop...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-106
更新日期:2010-05-12 00:00:00
abstract::The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized in this process, little is known about the functions of mTORC2 in cancer progression. In this study, we explor...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-57
更新日期:2010-03-12 00:00:00
abstract:BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-9-45
更新日期:2010-02-26 00:00:00